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osmotic f.
susceptibility of erythrocytes to rupture when subjected to increasingly hypotonic saline solutions; seen in some forms of hemolytic anemia and spherocytosis. See also osmotic fragility test, under test.
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osmotic fragility t.
(for spherocytosis): heparinized or defibrinated blood is placed in tubes of sodium chloride solution (pH 7.4) varying in concentration from 0.85 to 0.00 per cent (w/v); the amount of hemolysis in each tube is determined colorimetrically. Increased fragility indicates spherocytosis.
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osmotic n.
hypokalemic nephropathy.
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osmotic p.
the pressure required to stop osmosis through a semipermeable membrane between a solution and pure solvent; it is proportional to the osmolality of the solution and also to other colligative properties of the solution, including freezing point depression, vapor pressure depression, and boiling point elevation. Symbol π.
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osmotic p., effective
that part of the total osmotic pressure of a solution which governs the tendency of its solvent to pass through a semipermeable bounding membrane or across another boundary.
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